Lysine Impurity 43 DiHCl CAS 82951-55-1 (free base)
| CAS No. | 82951-55-1 (free base) |
| Molecular Formula | C11H21N3O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lysine Impurity 43 DiHCl (CAS 82951-55-1 (free base), C11H21N3O5SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lysine Impurity 43 DiHCl (C11H21N3O5SHCl) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lysine Impurity 43 DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H21N3O5S 2*HCl |
| Molecular Weight | 343.82 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lysine Standards
- L-Lysine Hydrochloride (CAS 10098-89-2)
- D-Lysine dihydrochloride (CAS 10303-72-7)
- Lysine Impurity 10 HCl (CAS 104584-11-4)
- L-Lysine-13C6,15N2 Hydrochloride (CAS 1200447-00-2)
- L-lysine-6-<SUP>13</SUP>C dihydrochloride (CAS 1217466-44-8)
- Lysine Impurity 25 (CAS 121893-23-0)
- Lysine Impurity 16 TFA Salt (CAS 13184-13-9(free base))
- L-Lysine-d4 Methyl Ester Dihydrochloride (CAS 1331896-92-4)
Recommended Standards
- Captopril Impurity 31 (CAS 69570-39-4)
- Ritonavir EP Impurity B (CAS 765875-58-9)
- Fluvastatin EP Impurity A Sodium Salt（and enantiomer） (CAS 93957-58-5)
- 3-(Piperidin-4-yl)propanenitrile (CAS 356045-72-2)
- Lenalidomide Lactosamine Adduct (Mixture of Diastereomers) (CAS CATO-C4X-190373)
- Ethyl 2-(4-(fluorosulfonyl)phenyl)-4-hydroxyquinoline-5-carboxylate (CAS 83803-43-4)
- 2-Chloro-N-(3-methoxyphenyl)pyrimidin-4-amine (CAS 191728-86-6)
- 4-Hydroxy-1,5-naphthyridine-3-carboxylic Acid (CAS 53512-10-0)
- (2-Bromo-4-chlorophenyl)(methyl)sulfane (CAS 452082-73-4)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
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